BDBM4301 (2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide::CHEMBL296407::Tyrphostin deriv. 40::benzylidenemalononitrile (BMN) deriv. 46

SMILES NC(=O)C(=C\c1ccc(O)c(O)c1)\C#N

InChI Key InChIKey=USOXQZNJFMKTKJ-XVNBXDOJSA-N

Data  1 KI  13 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 4301   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University of Jerusalem

LigandBDBM4301((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide...)Copy SMILESCopy InChI

Affinity DataKi:  3.50E+3nM IC50:  1.00E+4nMAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLMMDBPC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMed
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