BDBM4344 (2E)-2-cyano-3-(4-fluorophenyl)prop-2-enoic acid::benzylidenemalononitrile (BMN) deriv. 28

SMILES OC(=O)C(=C\c1ccc(F)cc1)\C#N

InChI Key InChIKey=OBZAFMILNGLRAL-VMPITWQZSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 4344   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University of Jerusalem

LigandPNGBDBM4344((2E)-2-cyano-3-(4-fluorophenyl)prop-2-enoic acid |...)
Affinity DataKi:  8.33E+5nM IC50:  2.50E+6nMAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Rattus norvegicus (Rat))
Medical School Duluth

Curated by ChEMBL
LigandPNGBDBM4344((2E)-2-cyano-3-(4-fluorophenyl)prop-2-enoic acid |...)
Affinity DataIC50:  500nMAssay Description:Inhibition of MCT1-mediated lactate transport in rat RBE4 cells incubated for 15 mins by [14C]-lactate uptake assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed