BDBM435774 1-((1S,3R)-5-(1-cyclopropyl- 1H-pyrazol-4-yl)-3- (hydroxymethyl)-1-methyl- 3,4-dihydroisoquinolin-2(1H)- yl)-2-(2,6- dichlorophenyl)ethan-1-one::US10611751, Example 3
SMILES C[C@@H]1N([C@@H](CO)Cc2c1cccc2-c1cnn(c1)C1CC1)C(=O)Cc1c(Cl)cccc1Cl
InChI Key InChIKey=HGQHLJRFATXYPS-MAUKXSAKSA-N
Data 3 EC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 435774
Affinity DataEC50: 287nMAssay Description:The PAM activity of the compounds of the present invention may be measured essentially as described in Svensson et al., An Allosteric Potentiator of ...More data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence ...More data for this Ligand-Target Pair
Affinity DataEC50: 287nMAssay Description:Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayMore data for this Ligand-Target Pair