BDBM435952 2-(2-chloro-6-fluorophenyl)-1-((1S,3R)-3-(hydroxymethyl)-1-methyl-5-(1H-pyrazol-4-yl)-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one::US10611751, Example 9

SMILES C[C@@H]1N([C@@H](CO)Cc2c1cccc2-c1cn[nH]c1)C(=O)Cc1c(F)cccc1Cl

InChI Key

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 435952   

TargetD(1A) dopamine receptor(Homo sapiens (Human))
Arrival Discovery

Curated by ChEMBL
LigandPNGBDBM435952(2-(2-chloro-6-fluorophenyl)-1-((1S,3R)-3-(hydroxym...)
Affinity DataEC50:  28nMAssay Description:Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Arrival Discovery

Curated by ChEMBL
LigandPNGBDBM435952(2-(2-chloro-6-fluorophenyl)-1-((1S,3R)-3-(hydroxym...)
Affinity DataEC50:  28nMAssay Description:The PAM activity of the compounds of the present invention may be measured essentially as described in Svensson et al., An Allosteric Potentiator of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent