BDBM437309 1-methyl-4-morpholino-5-(1-(1-phenylethyl)-1H- pyrazol-4-yl)pyridin-2(1H)-one::US10617680, Example 43::US11020380, Example 43

SMILES CC(c1ccccc1)n1cc(cn1)-c1cn(C)c(=O)cc1N1CCOCC1

InChI Key InChIKey=CXRSFLCEAGUDNZ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 437309   

TargetCREB-binding protein(Homo sapiens (Human))
Celgene Quanticel Research

US Patent
LigandPNGBDBM437309(1-methyl-4-morpholino-5-(1-(1-phenylethyl)-1H- pyr...)
Affinity DataIC50: <500nMAssay Description:The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCREB-binding protein(Homo sapiens (Human))
Celgene Quanticel Research

US Patent
LigandPNGBDBM437309(1-methyl-4-morpholino-5-(1-(1-phenylethyl)-1H- pyr...)
Affinity DataIC50: <500nMAssay Description:The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [42-168](Homo sapiens (Human))
Celgene Quanticel Research

US Patent
LigandPNGBDBM437309(1-methyl-4-morpholino-5-(1-(1-phenylethyl)-1H- pyr...)
Affinity DataIC50:  2.75E+3nMAssay Description:Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BRD4 was cloned, expr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCREB-binding protein(Homo sapiens (Human))
Celgene Quanticel Research

US Patent
LigandPNGBDBM437309(1-methyl-4-morpholino-5-(1-(1-phenylethyl)-1H- pyr...)
Affinity DataIC50: <500nMAssay Description:The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [42-168](Homo sapiens (Human))
Celgene Quanticel Research

US Patent
LigandPNGBDBM437309(1-methyl-4-morpholino-5-(1-(1-phenylethyl)-1H- pyr...)
Affinity DataIC50:  2.75E+3nMAssay Description:Inhibition of BRD4 was determined as described previously. See, e.g., U.S. Pat. No. 9,034,900.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent