BDBM444508 (R)-4-(1-benzylpyrrolidin-3-ylamino)-3-chloro- N-(thiazol-2-yl)benzenesulfonamide::US10662184, Example 79

SMILES Clc1cc(ccc1N[C@@H]1CCN(C1)c1ccccc1)S(=O)(=O)Nc1nccs1

InChI Key InChIKey=OKOHOURYIJIWAH-CQSZACIVSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 444508   

TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM444508((R)-4-(1-benzylpyrrolidin-3-ylamino)-3-chloro- N-(...)
Affinity DataIC50: >1.00E+4nMAssay Description:The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM444508((R)-4-(1-benzylpyrrolidin-3-ylamino)-3-chloro- N-(...)
Affinity DataIC50:  138nMAssay Description:The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent