BDBM444514 (R)-4-(1-benzylpyrrolidin-3-ylamino)-5-chloro- 2-fluoro-N-(thiazol-2-yl)benzenesulfonamide::US10662184, Example 89

SMILES Fc1cc(N[C@@H]2CCN(C2)c2ccccc2)c(Cl)cc1S(=O)(=O)Nc1nccs1

InChI Key InChIKey=IXJXVJVVOXLEOM-CYBMUJFWSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 444514   

TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM444514((R)-4-(1-benzylpyrrolidin-3-ylamino)-5-chloro- 2-f...)
Affinity DataIC50:  2.87E+3nMAssay Description:The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM444514((R)-4-(1-benzylpyrrolidin-3-ylamino)-5-chloro- 2-f...)
Affinity DataIC50:  91nMAssay Description:The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent