BDBM444536 5-chloro-4-(((S)-1-((S)-2,3-dihydro-1H-inden-1-yl)pyrrolidin-3-yl)(methyl)amino)-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide 2,2,2-trifluoroacetate::US10662184, Example 249

SMILES CN([C@H]1CCN(C1)C1CCc2ccccc12)c1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1

InChI Key InChIKey=LHOQAADZGRIBMK-DJZRFWRSSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 444536   

TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM444536(5-chloro-4-(((S)-1-((S)-2,3-dihydro-1H-inden-1-yl)...)
Affinity DataIC50: >1.00E+4nMAssay Description:The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM444536(5-chloro-4-(((S)-1-((S)-2,3-dihydro-1H-inden-1-yl)...)
Affinity DataIC50:  110nMAssay Description:The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent