BDBM444568 US10662186, Compound 87::US10988476, Compound I-87

SMILES Cc1nc2c(F)cc(cc2n1C1(C)CC1)-c1nc(Nc2ccc3CNCCc3n2)ncc1F

InChI Key InChIKey=BONJLZFNDLMWRE-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 444568   

TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding

US Patent
LigandPNGBDBM444568(US10662186, Compound 87 | US10988476, Compound I-8...)
Affinity DataIC50:  0.920nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 6(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding

US Patent
LigandPNGBDBM444568(US10662186, Compound 87 | US10988476, Compound I-8...)
Affinity DataIC50:  2.21nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding

US Patent
LigandPNGBDBM444568(US10662186, Compound 87 | US10988476, Compound I-8...)
Affinity DataIC50:  10.3nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding

US Patent
LigandPNGBDBM444568(US10662186, Compound 87 | US10988476, Compound I-8...)
Affinity DataIC50:  0.920nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 6(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding

US Patent
LigandPNGBDBM444568(US10662186, Compound 87 | US10988476, Compound I-8...)
Affinity DataIC50:  2.21nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding

US Patent
LigandPNGBDBM444568(US10662186, Compound 87 | US10988476, Compound I-8...)
Affinity DataIC50:  10.3nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent