BDBM446828 (1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-[(4- methylphenyl)methoxy]bicyclo[3.1.0]hexane-2.6- dicarboxylic acid::US10689327, Compound (II)-12

SMILES Cc1ccc(CO[C@@H]2C[C@@H]3[C@@H]([C@@]3(F)C(O)=O)[C@]2(N)C(O)=O)cc1

InChI Key InChIKey=CVAFGISXRYNCDR-POPZOMSYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 446828   

TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM446828((1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-[(4- methylphe...)
Affinity DataIC50:  54.4nMAssay Description:CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM446828((1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-[(4- methylphe...)
Affinity DataIC50:  24.6nMAssay Description:CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent