BDBM446836 (1S,2R,3R,5R,6S)-2-amino-3-[(3,4- difluorophenyl)methoxy]bicyclo[3.1.0]hexane-2,6- dicarboxylic acid::US10689327, Compound (II)-14

SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccc(F)c(F)c1)[C@@H]2C(O)=O)C(O)=O

InChI Key InChIKey=OKBTYHHXUOFYFO-GTBYETLCSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 446836   

TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM446836((1S,2R,3R,5R,6S)-2-amino-3-[(3,4- difluorophenyl)m...)
Affinity DataIC50:  15.2nMAssay Description:CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM446836((1S,2R,3R,5R,6S)-2-amino-3-[(3,4- difluorophenyl)m...)
Affinity DataIC50:  30.1nMAssay Description:CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent