BDBM449875 US10703751, Example 1::US10703751, Example 5::trans-2-[4-[2-[1-Hydroxyethyl]-6-(methylamino)imidazo[4,5-c]pyridin-1-yl]cyclohexyl]acetonitrile

SMILES CNc1cc2n([C@H]3CC[C@H](CC#N)CC3)c(nc2cn1)C(C)O

InChI Key InChIKey=ROANNSYULQYJLV-VLXSWZPNSA-N

Data  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 449875   

TargetTyrosine-protein kinase JAK1 [850-1154](Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM449875(US10703751, Example 1 | US10703751, Example 5 | tr...)
Affinity DataEC50:  10.8nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM449875(US10703751, Example 1 | US10703751, Example 5 | tr...)
Affinity DataEC50:  530nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM449875(US10703751, Example 1 | US10703751, Example 5 | tr...)
Affinity DataEC50:  5.26E+3nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2 [871-1187](Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM449875(US10703751, Example 1 | US10703751, Example 5 | tr...)
Affinity DataEC50:  102nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1 [850-1154](Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM449875(US10703751, Example 1 | US10703751, Example 5 | tr...)
Affinity DataEC50:  8.41nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM449875(US10703751, Example 1 | US10703751, Example 5 | tr...)
Affinity DataEC50:  301nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM449875(US10703751, Example 1 | US10703751, Example 5 | tr...)
Affinity DataEC50:  3.20E+3nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2 [871-1187](Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM449875(US10703751, Example 1 | US10703751, Example 5 | tr...)
Affinity DataEC50:  111nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent