BDBM450046 9-{[1-(1-Azabicyclo[2.2.2]oct-3-ylmethyl)-1H-pyrazol-4-yl]methyl}-2-ethoxy-8-(5-fluoropyridin-3-yl)-6-methyl-9H-purine::US10703755, Example 163

SMILES CCOc1nc(C)c2nc(-c3cncc(F)c3)n(Cc3cnn(CC4CN5CCC4CC5)c3)c2n1

InChI Key InChIKey=NKDZCISFCIMWIN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 450046   

TargetToll-like receptor 7(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM450046(9-{[1-(1-Azabicyclo[2.2.2]oct-3-ylmethyl)-1H-pyraz...)
Affinity DataIC50:  10nMAssay Description:As human TLR7 expressing cell line, HEK293 cell line was bought from IMGENEX Corporation (TLR7/NF-ηB/SEAPorter™ HEK293 cell), which is human emb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent