BDBM450192 9-{4-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-2-fluorobenzyl}-8-(5-fluoropyridin-3-yl)-2-methoxy-6-methyl-9H-purine::US10703755, Example 392::US10703755, Example 402

SMILES COc1nc(C)c2nc(-c3cncc(F)c3)n(Cc3ccc(cc3F)[C@@H]3CN4CCC3CC4)c2n1

InChI Key InChIKey=BEYJDNZENUVEJF-OAQYLSRUSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 450192   

TargetToll-like receptor 7(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM450192(9-{4-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-2-fluorobe...)
Affinity DataIC50:  132nMAssay Description:As human TLR7 expressing cell line, HEK293 cell line was bought from IMGENEX Corporation (TLR7/NF-ηB/SEAPorter™ HEK293 cell), which is human emb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM450192(9-{4-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-2-fluorobe...)
Affinity DataIC50:  13nMAssay Description:As human TLR7 expressing cell line, HEK293 cell line was bought from IMGENEX Corporation (TLR7/NF-ηB/SEAPorter™ HEK293 cell), which is human emb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent