BDBM451125 US10676485, Example 35
SMILES CN1CCN(C[C@@H]2COc3ccc(OCc4ccnc(n4)C4=CC[C@](F)(COC[C@@H]5COCCO5)CC4)c(C[C@@H](Oc4ncnc5sc(C6=CCCC6)c(-c6c(C)c(Cl)c(O2)c(Cl)c6C)c45)C(O)=O)c3)CC1
InChI Key InChIKey=HKHRPKLZFOOZTA-ROKVPCLXSA-N
Data 2 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 451125
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataKi: 0.0270nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataKi: 0.520nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair