BDBM451156 US10676499, Example 53

SMILES COc1cc(ccc1C[n+]1cn([C@H]2O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]2O)c2nc(N)nc([O-])c12)-c1ccccc1

InChI Key InChIKey=YHMVJFYSAZOQAW-UDSSINMLSA-N

Data  1 KI  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 451156   

TargetEukaryotic translation initiation factor 4E(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM451156(US10676499, Example 53)
Affinity DataKi:  190nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEukaryotic translation initiation factor 4E(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM451156(US10676499, Example 53)
Affinity DataKd:  6.00E+3nMAssay Description:A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent