BDBM451744 6-(2-amino-5-(2-fluoro-4- nitrophenyl)pyridin-3-yl)-3,4- dihydroisoquinolin-1(2H)-one::US10710978, Compound I-54

SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1ccc(cc1F)[N+]([O-])=O

InChI Key InChIKey=WWJHZXNRYXBMPP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 451744   

TargetSerine/threonine-protein kinase 4(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM451744(6-(2-amino-5-(2-fluoro-4- nitrophenyl)pyridin-3-yl...)
Affinity DataIC50:  120nMAssay Description:Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase 26(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM451744(6-(2-amino-5-(2-fluoro-4- nitrophenyl)pyridin-3-yl...)
Affinity DataIC50: >1.00E+3nMAssay Description:Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase 24(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM451744(6-(2-amino-5-(2-fluoro-4- nitrophenyl)pyridin-3-yl...)
Affinity DataIC50: >1.00E+3nMAssay Description:Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase 3(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM451744(6-(2-amino-5-(2-fluoro-4- nitrophenyl)pyridin-3-yl...)
Affinity DataIC50: >1.00E+3nMAssay Description:Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent