BDBM451750 6-(2-amino-5-(2-methoxy-4- (thiazol-2-yl)phenyl)pyridin- 3-yl)-3,4-dihydroisoquinolin- 1(2H)-one::US10710978, Compound I-60

SMILES COc1cc(ccc1-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1)-c1nccs1

InChI Key InChIKey=HISUPVQNZBJUNP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 451750   

TargetSerine/threonine-protein kinase 4(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM451750(6-(2-amino-5-(2-methoxy-4- (thiazol-2-yl)phenyl)py...)
Affinity DataIC50:  120nMAssay Description:Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase 26(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM451750(6-(2-amino-5-(2-methoxy-4- (thiazol-2-yl)phenyl)py...)
Affinity DataIC50: >1.00E+3nMAssay Description:Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase 24(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM451750(6-(2-amino-5-(2-methoxy-4- (thiazol-2-yl)phenyl)py...)
Affinity DataIC50: >1.00E+3nMAssay Description:Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase 3(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM451750(6-(2-amino-5-(2-methoxy-4- (thiazol-2-yl)phenyl)py...)
Affinity DataIC50: >1.00E+3nMAssay Description:Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent