BDBM453026 (2R,3R,4S,5S)-2-(4-amino- 7H-pyrrolo[2,3-d]pyrimidin-7- yl)-5-((R)-6,7- dichloroisochroman-1- yl)tetrahydrofuran-3,4-diol::US10711007, Example 88::US11214574, Ex# 88::US11254683, Example 88
SMILES Nc1ncnc2n(ccc12)[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)[C@@H]1OCCc2cc(Cl)c(Cl)cc12
InChI Key InChIKey=JZUYFQWEDPPVCE-IPXJXJKCSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 453026
Affinity DataIC50: 1.60nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0,...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0,...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics
US Patent
Prelude Therapeutics
US Patent
Affinity DataIC50: 1.60nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0,...More data for this Ligand-Target Pair