BDBM455047 US10730874, Compound I-104a::US10730874, Compound I-104b::US10730874, Compound I-71::US11352356, Compound I-71

SMILES CCOC(=O)c1cc(cn2cc(Cn3cc(cn3)C(=O)NCc3ncn4ccc(Cl)cc34)nc12)C1CC1

InChI Key InChIKey=LYXCZPOSBFRUCX-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 455047   

TargetPlasma kallikrein(Homo sapiens (Human))
Shire Human Genetic Therapies

US Patent
LigandPNGBDBM455047(US10730874, Compound I-104a | US10730874, Compound...)
Affinity DataEC50: <1nMAssay Description:Example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing a fluorogenic peptide s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Shire Human Genetic Therapies

US Patent
LigandPNGBDBM455047(US10730874, Compound I-104a | US10730874, Compound...)
Affinity DataEC50: <1nMAssay Description:Example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing a fluorogenic peptide s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Shire Human Genetic Therapies

US Patent
LigandPNGBDBM455047(US10730874, Compound I-104a | US10730874, Compound...)
Affinity DataEC50: <1nMAssay Description:Example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing a fluorogenic peptide s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Shire Human Genetic Therapies

US Patent
LigandPNGBDBM455047(US10730874, Compound I-104a | US10730874, Compound...)
Affinity DataEC50: <1nMAssay Description:Example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing a fluorogenic peptide s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent