BDBM455381 4-(1-(3-ethyl-1-((trifluoromethyl)sulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazine::US10730880, Example 48

SMILES CCC1(CN(C1)S(=O)(=O)C(F)(F)F)n1cc(cn1)-c1nc(cn2nccc12)C1C=N[N](C)=C1

InChI Key InChIKey=HLIPGWJBEYZPDC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 455381   

TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM455381(4-(1-(3-ethyl-1-((trifluoromethyl)sulfonyl)azetidi...)
Affinity DataIC50: <10nMAssay Description:Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM455381(4-(1-(3-ethyl-1-((trifluoromethyl)sulfonyl)azetidi...)
Affinity DataIC50:  5.50E+3nMAssay Description:Compounds of Formula I were screened for their ability to inhibit JAK3 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM455381(4-(1-(3-ethyl-1-((trifluoromethyl)sulfonyl)azetidi...)
Affinity DataIC50: <10nMAssay Description:Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM455381(4-(1-(3-ethyl-1-((trifluoromethyl)sulfonyl)azetidi...)
Affinity DataIC50:  55nMAssay Description:Compounds of Formula I were screened for their ability to inhibit JAK1 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent