BDBM456063 US10723723, Example 21-I::US10723723, Example 21-II::US10723723, Example 22-I

SMILES CN(CC(O)c1ccc2C(=O)OCc2c1C)Cc1ccc(nc1)-c1ccc(C#N)c(F)c1

InChI Key InChIKey=LXVOFHFNOVWHGP-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 456063   

TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM456063(US10723723, Example 21-I | US10723723, Example 21-...)
Affinity DataIC50:  18nMAssay Description:The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2), 1 Mg...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM456063(US10723723, Example 21-I | US10723723, Example 21-...)
Affinity DataIC50:  53nMAssay Description:The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2), 1 Mg...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM456063(US10723723, Example 21-I | US10723723, Example 21-...)
Affinity DataIC50:  270nMAssay Description:Solutions and reagents: Thallium flux assay was performed using FluxOR kit (F10017, Life Technologies). Loading buffer, assay buffer and stimulus buf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM456063(US10723723, Example 21-I | US10723723, Example 21-...)
Affinity DataIC50:  350nMAssay Description:Solutions and reagents: Thallium flux assay was performed using FluxOR kit (F10017, Life Technologies). Loading buffer, assay buffer and stimulus buf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM456063(US10723723, Example 21-I | US10723723, Example 21-...)
Affinity DataIC50:  86nMAssay Description:Solutions and reagents: Thallium flux assay was performed using FluxOR kit (F10017, Life Technologies). Loading buffer, assay buffer and stimulus buf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent