BDBM456178 (R)-5-(1-hydroxy-2-(((2- (4-methyl-1H-imidazol- 1-yl)pyrimidin-5- yl)methyl)amino)ethyl)- 4-methylisobenzofuran- 1(3H)one::US10723723, Example 106

SMILES Cc1cn(cn1)-c1ncc(CNC[C@H](O)c2ccc3C(=O)OCc3c2C)cn1

InChI Key InChIKey=LWRVSJDWNGHTRN-SFHVURJKSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 456178   

TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM456178((R)-5-(1-hydroxy-2-(((2- (4-methyl-1H-imidazol- 1-...)
Affinity DataIC50:  26nMAssay Description:Solutions and reagents: Thallium flux assay was performed using FluxOR kit (F10017, Life Technologies). Loading buffer, assay buffer and stimulus buf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM456178((R)-5-(1-hydroxy-2-(((2- (4-methyl-1H-imidazol- 1-...)
Affinity DataIC50:  9.20nMAssay Description:The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2), 1 Mg...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent