BDBM456196 (R)-3-(difluoromethyl)-1- (5-(((2-hydroxy-2-(4- methyl-1-oxo-1,3- dihydroisobenzofuran-5- yl)ethyl)amino)methyl) pyrimidin-2-yl)-1H-pyrazole- 4-carbonitrile::US10723723, Example 115

SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CNCc1cnc(nc1)-n1cc(C#N)c(n1)C(F)F

InChI Key InChIKey=DPGVCXACDOUKDA-KRWDZBQOSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 456196   

TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM456196((R)-3-(difluoromethyl)-1- (5-(((2-hydroxy-2-(4- me...)
Affinity DataIC50:  20nMAssay Description:The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2), 1 Mg...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM456196((R)-3-(difluoromethyl)-1- (5-(((2-hydroxy-2-(4- me...)
Affinity DataIC50:  20nMAssay Description:Solutions and reagents: Thallium flux assay was performed using FluxOR kit (F10017, Life Technologies). Loading buffer, assay buffer and stimulus buf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent