BDBM456198 (R)-3-cyclopropyl-1-(5- (((2-hydroxy-2-(4-methyl- 1-oxo-1,3- dihydroisobenzofuran-5- yl)ethyl)amino)methyl) pyridin-2-yl)-1H-pyrazole-4- carbonitrile::US10723723, Example 116

SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CNCc1ccc(nc1)-n1cc(C#N)c(n1)C1CC1

InChI Key InChIKey=JYVHDLOOORQHHA-NRFANRHFSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 456198   

TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM456198((R)-3-cyclopropyl-1-(5- (((2-hydroxy-2-(4-methyl- ...)
Affinity DataIC50:  20nMAssay Description:Solutions and reagents: Thallium flux assay was performed using FluxOR kit (F10017, Life Technologies). Loading buffer, assay buffer and stimulus buf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent