BDBM456207 (R)-6-(3-(difluoromethyl)- 4-(((2-hydroxy-2-(4- methyl-1-oxo-1,3- dihydroisobenzofuran-5- yl)ethyl)amino)methyl)- 1H-pyrazol-1-yl)-4- methylnicotinonitrile::US10723723, Example 93

SMILES Cc1cc(ncc1C#N)-n1cc(CNC[C@H](O)c2ccc3C(=O)OCc3c2C)c(n1)C(F)F

InChI Key InChIKey=AKLSFEFCBKOPIX-IBGZPJMESA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 456207   

TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM456207((R)-6-(3-(difluoromethyl)- 4-(((2-hydroxy-2-(4- me...)
Affinity DataIC50:  15nMAssay Description:Solutions and reagents: Thallium flux assay was performed using FluxOR kit (F10017, Life Technologies). Loading buffer, assay buffer and stimulus buf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent