BDBM456247 (R)-6-(5-(((2-hydroxy-2- (4-methyl-1-oxo-1,3- dihydroisobenzofuran-5- yl)ethyl)amino)methyl) isoxazol-3-yl)-4- methylnicotinonitrile::US10723723, Example 140
SMILES Cc1cc(ncc1C#N)-c1cc(CNC[C@H](O)c2ccc3C(=O)OCc3c2C)on1
InChI Key InChIKey=LULRSIJEMWMGOQ-NRFANRHFSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 456247
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Bristol-Myers Squibb
US Patent
Bristol-Myers Squibb
US Patent
Affinity DataIC50: 16nMAssay Description:The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2), 1 Mg...More data for this Ligand-Target Pair
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Bristol-Myers Squibb
US Patent
Bristol-Myers Squibb
US Patent
Affinity DataIC50: 56nMAssay Description:Solutions and reagents: Thallium flux assay was performed using FluxOR kit (F10017, Life Technologies). Loading buffer, assay buffer and stimulus buf...More data for this Ligand-Target Pair