BDBM456279 6-(4-(((2-(4-cyclopropyl-1- oxo-1,3- dihydroisobenzofuran-5- yl)2- hydroxyethyl)amino)meth- yl)-1H-pyrazol-1-yl)-4- methylnicotinonitrile (Enantiomer-I)::US10723723, Example 46-I

SMILES Cc1cc(ncc1C#N)-n1cc(CNCC(O)c2ccc3C(=O)OCc3c2C2CC2)cn1

InChI Key InChIKey=IJMLWYCMZSJRPA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 456279   

TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM456279(6-(4-(((2-(4-cyclopropyl-1- oxo-1,3- dihydroisoben...)
Affinity DataIC50:  17nMAssay Description:The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2), 1 Mg...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM456279(6-(4-(((2-(4-cyclopropyl-1- oxo-1,3- dihydroisoben...)
Affinity DataIC50:  33nMAssay Description:Solutions and reagents: Thallium flux assay was performed using FluxOR kit (F10017, Life Technologies). Loading buffer, assay buffer and stimulus buf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent