BDBM457088 N-(1,2,4-thiadiazol-5-yl)-6-(5- (4-(trifluoromethyl)phenyl)- 3,4-dihydroisoquinolin-2(1H)- yl)pyridine-2-sulfonamide::US10738026, Compound 29::US11401258, Compound 29

SMILES FC(F)(F)c1ccc(cc1)-c1cccc2CN(CCc12)c1cccc(n1)S(=O)(=O)Nc1ncns1

InChI Key InChIKey=SBKIFLXSGDXZHF-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 457088   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM457088(N-(1,2,4-thiadiazol-5-yl)-6-(5- (4-(trifluoromethy...)
Affinity DataKi:  535nMAssay Description:On the day of experimentation, cells are prepared by removing media and digesting with appropriate enzymes to suspend cells in external solution.Whol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM457088(N-(1,2,4-thiadiazol-5-yl)-6-(5- (4-(trifluoromethy...)
Affinity DataKi:  535nMAssay Description:Manual Electrophysiology: On the day of experimentation, the 35 mm dish is placed on the stage of an inverted microscope equipped with a perfusion sy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM457088(N-(1,2,4-thiadiazol-5-yl)-6-(5- (4-(trifluoromethy...)
Affinity DataIC50:  291nMAssay Description:Assay Buffer: The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM457088(N-(1,2,4-thiadiazol-5-yl)-6-(5- (4-(trifluoromethy...)
Affinity DataIC50:  291nMAssay Description:The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL of 10×HBSS th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent