BDBM457801 9,9′-((1R,6R,8R,9R,14R,16R,17S,18S)-3,11,17,18-tetrahydroxy-3,11-disulfido-2,4,10,12-tetraoxa-7,15-dithia-3,11-diphosphatricyclo[12.2.1.16,9]octadecane-8,16-diyl)bis(2-amino-1,9-dihydro-6H-purin-6-one) (Diastereomers 1 and 2)::US10738074, Example 28::US10738074, Example 29

SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1S[C@@H]2COP(O)(=S)O[C@@H]3[C@H](O)[C@@H](COP(O)(=S)O[C@@H]1[C@@H]2O)S[C@H]3n1cnc2c1nc(N)[nH]c2=O

InChI Key

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 457801   

TargetStimulator of interferon genes protein [H232R](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM457801(9,9′-((1R,6R,8R,9R,14R,16R,17S,18S)-3,11,17,...)
Affinity DataEC50:  178nMAssay Description:16 nM of [3H] c-GAMP ligand was prepared by diluting into assay buffer, and 50 uL of this working stock was manually added to each well of the assay ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein [H232R](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM457801(9,9′-((1R,6R,8R,9R,14R,16R,17S,18S)-3,11,17,...)
Affinity DataEC50:  13.8nMAssay Description:16 nM of [3H] c-GAMP ligand was prepared by diluting into assay buffer, and 50 uL of this working stock was manually added to each well of the assay ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent