BDBM458247 US10752615, Compound 145

SMILES CNc1cc(ncn1)-c1ccc(s1)C(=O)Nc1nc2ccccc2n1[C@H]1C[C@]2(C1)CCN(C2)C(=O)C=C

InChI Key InChIKey=FHNCSRKSWPZETL-KJGDFQNHSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 458247   

TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Gb005

US Patent
LigandPNGBDBM458247(US10752615, Compound 145)
Affinity DataIC50:  1.28nMAssay Description:The in vitro kinase assays were performed at Nanosyn (Santa Clara, Calif.) utilizing microfluidic detection technology. The test compounds were seria...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Tec(Homo sapiens (Human))
Gb005

US Patent
LigandPNGBDBM458247(US10752615, Compound 145)
Affinity DataIC50:  0.180nMAssay Description:The in vitro kinase assays were performed at Nanosyn (Santa Clara, Calif.) utilizing microfluidic detection technology. The test compounds were seria...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Gb005

US Patent
LigandPNGBDBM458247(US10752615, Compound 145)
Affinity DataIC50:  0.490nMAssay Description:The in vitro kinase assays were performed at Nanosyn (Santa Clara, Calif.) utilizing microfluidic detection technology. The test compounds were seria...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase TXK(Homo sapiens (Human))
Gb005

US Patent
LigandPNGBDBM458247(US10752615, Compound 145)
Affinity DataIC50:  0.200nMAssay Description:The in vitro kinase assays were performed at Nanosyn (Santa Clara, Calif.) utilizing microfluidic detection technology. The test compounds were seria...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent