BDBM458782 US10759766, Compound C145

SMILES Fc1cc(NC(=O)c2cccc(c2)C(F)(F)F)cc(C(=O)c2ccc3ncc(nc3c2)N2CCOCC2)c1F

InChI Key InChIKey=CXWJKNYPVSWOKG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 458782   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Neupharma

US Patent
LigandPNGBDBM458782(US10759766, Compound C145)
Affinity DataIC50: <100nMAssay Description:KDR (VEGFR2): Inhibitory activities of compounds against KDR (VEGFR2) were also measured by Invitrogen using Z′-LYTEŽ Method as described above...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Neupharma

US Patent
LigandPNGBDBM458782(US10759766, Compound C145)
Affinity DataIC50: <100nMAssay Description:BRAF and BRAF V600E: Inhibitory activities Inhibitory activities of compounds against BRAF, and BRAF V600E were measured by Invitrogen using Z′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent