BDBM458816 N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-methyl-6-(methyl(tetrahydro-2H-pyran-4-yl)amino)benzofuran-4-carboxamide::US10759787, Example 23::US11059811, Example 23

SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)c(cc2occc12)N(C)C1CCOCC1

InChI Key InChIKey=PXZDJRDWPVLPHE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 458816   

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM458816(N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-...)
Affinity DataIC50:  4.80nMAssay Description:The activity of EZH2 enzyme (with A677G mutant or Y641F mutant) was tested by the following method.The method was used to determine the inhibitory ef...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM458816(N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-...)
Affinity DataIC50:  0.300nMAssay Description:The activity of EZH2 enzyme (with A677G mutant or Y641F mutant) was tested by the following method.The method was used to determine the inhibitory ef...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2 [A677G](Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM458816(N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-...)
Affinity DataIC50:  4.80nMAssay Description:The activity of EZH2 enzyme (with A677G mutant or Y641F mutant) was tested by the following method.The method was used to determine the inhibitory ef...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM458816(N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-...)
Affinity DataIC50:  0.300nMAssay Description:The activity of EZH2 enzyme (with A677G mutant or Y641F mutant) was tested by the following method.The method was used to determine the inhibitory ef...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent