BDBM458820 5-Ethyl-6-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-fluoro-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)benzofuran-4-carboxamide::US10759787, Example 27::US11059811, Example 27

SMILES CCN(C1CCOCC1)c1cc2oc(F)cc2c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1CC

InChI Key InChIKey=PBVRBTBVYDGIDL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 458820   

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM458820(5-Ethyl-6-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2...)
Affinity DataIC50:  3.5nMAssay Description:The activity of EZH2 enzyme (with A677G mutant or Y641F mutant) was tested by the following method.The method was used to determine the inhibitory ef...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2 [A677G](Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM458820(5-Ethyl-6-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2...)
Affinity DataIC50:  3.5nMAssay Description:The activity of EZH2 enzyme (with A677G mutant or Y641F mutant) was tested by the following method.The method was used to determine the inhibitory ef...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent