BDBM459441 US10752635, Example 3, Peak 1::US11492354, Example 3, Peak 2

SMILES COc1cccc(F)c1-c1nccc(n1)C(=O)Nc1cc(F)c2n(C)ncc2c1N1C[C@@H](N)C[C@H]1CO

InChI Key InChIKey=HUAPVUVLSXALII-KBPBESRZSA-N

Data  3 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 459441   

LigandPNGBDBM459441(US10752635, Example 3, Peak 1 | US11492354, Exampl...)
Affinity DataKi:  2.20nMAssay Description:In vitro inhibition of human carbonic anhydrase II (0.1 nM).More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM459441(US10752635, Example 3, Peak 1 | US11492354, Exampl...)
Affinity DataKi: <100nMAssay Description:A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM459441(US10752635, Example 3, Peak 1 | US11492354, Exampl...)
Affinity DataKi: <100nMAssay Description:A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM459441(US10752635, Example 3, Peak 1 | US11492354, Exampl...)
Affinity DataIC50:  400nMAssay Description:In vitro for inhibition of rat HMG-CoA reductase.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase 4(Homo sapiens (Human))TBA
LigandPNGBDBM459441(US10752635, Example 3, Peak 1 | US11492354, Exampl...)
Affinity DataIC50:  201nMAssay Description:Histamine H2 receptor antagonism on the right atrium of the guinea pigMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM459441(US10752635, Example 3, Peak 1 | US11492354, Exampl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against human carbonic anhydrase II using pH stat assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM459441(US10752635, Example 3, Peak 1 | US11492354, Exampl...)
Affinity DataIC50:  530nMAssay Description:Inhibitory activity against Dihydrofolate reductase obtained from rat liver; Range 260-370More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed