BDBM459444 US10752635, Example 4, Peak 2::US11492354, Example 4, Peak 2

SMILES COc1cccc(F)c1-c1nccc(n1)C(=O)Nc1cc(F)c2nn(C)cc2c1N1CC[C@@H](N)C1

InChI Key InChIKey=FKWAGVCCEZPSSL-CYBMUJFWSA-N

Data  4 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 459444   

LigandPNGBDBM459444(US10752635, Example 4, Peak 2 | US11492354, Exampl...)
Affinity DataKi: <1nMAssay Description:Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM459444(US10752635, Example 4, Peak 2 | US11492354, Exampl...)
Affinity DataKi: <100nMAssay Description:A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM459444(US10752635, Example 4, Peak 2 | US11492354, Exampl...)
Affinity DataKi: <100nMAssay Description:A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM459444(US10752635, Example 4, Peak 2 | US11492354, Exampl...)
Affinity DataKi:  100nMAssay Description:Antagonistic activity against Thromboxane A2 receptor in rat aorta in the presence of 11,9-epoxymethano-PGH2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM459444(US10752635, Example 4, Peak 2 | US11492354, Exampl...)
Affinity DataIC50:  643nMAssay Description:The compound was tested for beta-adrenergic activity against Beta-2 adrenergic receptor from guinea pig trachea.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM459444(US10752635, Example 4, Peak 2 | US11492354, Exampl...)
Affinity DataIC50:  73nMAssay Description:Inhibitory activity against human carbonic anhydrase II using pH stat assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed