BDBM461250 6-(3-(2-chloro-4-((3-(2,6- dichloro-4-fluorophenyl)-5- methylisoxazol-4- yl)methoxy)phenyl)-3- hydroxyazetidin-1-yl)-5- fluoronicotinic acid::US10774054, Example 4::US10981881, Example 4
SMILES Cc1onc(c1COc1ccc(c(Cl)c1)C1(O)CN(C1)c1ncc(cc1F)C(O)=O)-c1c(Cl)cc(F)cc1Cl
InChI Key InChIKey=BMIKSEZPOBHKOJ-UHFFFAOYSA-N
Data 4 EC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 461250
Affinity DataEC50: 35nMAssay Description:Preparation of human FXR alpha ligand binding domain: The human FXRalpha LBD was expressed in E. coli strain BL21(DE3) as an N-terminally GST tagged ...More data for this Ligand-Target Pair
Affinity DataEC50: 176nMAssay Description:Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR was performed as follow...More data for this Ligand-Target Pair
Affinity DataEC50: 35nMAssay Description:Determination of a ligand mediated cofactor peptide interaction to quantify ligand binding to the nuclear receptor FXR was performed as follows.Prepa...More data for this Ligand-Target Pair
Affinity DataEC50: 176nMAssay Description:The cDNA part encoding the FXR ligand binding domain was cloned into vector pCMV-BD (Stratagene) as a fusion to the yeast GAL4 DNA binding domain und...More data for this Ligand-Target Pair