BDBM461253 2-(6-(3-(2-chloro-4-((5- cyclopropyl-3-(2,6-dichloro-4- fluorophenyl)isoxazol-4- yl)methoxy)phenyl)-3- hydroxyazetidin-1-yl)-5- fluoronicotinamido)ethane-1- sulfonic acid::US10774054, Example 7::US10981881, Example 7
SMILES OC1(CN(C1)c1ncc(cc1F)C(=O)NCCS(O)(=O)=O)c1ccc(OCc2c(onc2-c2c(Cl)cc(F)cc2Cl)C2CC2)cc1Cl
InChI Key InChIKey=KJZKXTMRYZAFGL-UHFFFAOYSA-N
Data 4 EC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 461253
Affinity DataEC50: 6.90nMAssay Description:Preparation of human FXR alpha ligand binding domain: The human FXRalpha LBD was expressed in E. coli strain BL21(DE3) as an N-terminally GST tagged ...More data for this Ligand-Target Pair
Affinity DataEC50: 1.70E+3nMAssay Description:Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR was performed as follow...More data for this Ligand-Target Pair
Affinity DataEC50: 6.90nMAssay Description:Determination of a ligand mediated cofactor peptide interaction to quantify ligand binding to the nuclear receptor FXR was performed as follows.Prepa...More data for this Ligand-Target Pair
Affinity DataEC50: 1.70E+3nMAssay Description:The cDNA part encoding the FXR ligand binding domain was cloned into vector pCMV-BD (Stratagene) as a fusion to the yeast GAL4 DNA binding domain und...More data for this Ligand-Target Pair