BDBM461254 (6-(3-(2-chloro-4-((5- cyclopropyl-3-(2,6-dichloro-4- fluorophenyl)isoxazol-4- yl)methoxy)phenyl)-3- hydroxyazetidin-1-yl)-5- fluoronicotinoyl)glycine::US10774054, Example 8::US10981881, Example 8
SMILES OC(=O)CNC(=O)c1cnc(N2CC(O)(C2)c2ccc(OCc3c(onc3-c3c(Cl)cc(F)cc3Cl)C3CC3)cc2Cl)c(F)c1
InChI Key InChIKey=ZNKGESDUKQTOIG-UHFFFAOYSA-N
Data 4 EC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 461254
Affinity DataEC50: 8.10nMAssay Description:Preparation of human FXR alpha ligand binding domain: The human FXRalpha LBD was expressed in E. coli strain BL21(DE3) as an N-terminally GST tagged ...More data for this Ligand-Target Pair
Affinity DataEC50: 1.26E+3nMAssay Description:Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR was performed as follow...More data for this Ligand-Target Pair
Affinity DataEC50: 8.10nMAssay Description:Determination of a ligand mediated cofactor peptide interaction to quantify ligand binding to the nuclear receptor FXR was performed as follows.Prepa...More data for this Ligand-Target Pair
Affinity DataEC50: 1.26E+3nMAssay Description:The cDNA part encoding the FXR ligand binding domain was cloned into vector pCMV-BD (Stratagene) as a fusion to the yeast GAL4 DNA binding domain und...More data for this Ligand-Target Pair