BDBM461758 US10774071, Example B-225
SMILES COc1nc(O[C@H]2CCc3c2cccc3-c2cccc(c2Cl)-c2cnc(CNC[C@@H]3CCC(=O)N3)c(OC)n2)c(cc1CNC1(CC1)C(O)=O)C(F)(F)F
InChI Key InChIKey=GMUOLKGMNIXZRE-JRPXNJEYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 461758
TargetProgrammed cell death 1 ligand 1 [19-238]/protein 1 [25-167](Homo sapiens (Human))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataEC50: 19nMAssay Description:Compounds were tested in a functional co-culture reporter assay in which TCR-mediated NFAT activity is inhibited by the engagement of PD-1 with PD-L1...More data for this Ligand-Target Pair
TargetProgrammed cell death 1 ligand 1 [19-238]/protein 1 [25-167](Homo sapiens (Human))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 0.0640nMAssay Description:Compounds were tested in biochemical protein-protein interaction assays to determine if they can specifically block the interaction between the extra...More data for this Ligand-Target Pair