BDBM468007 (R)-N-(1-Acryloylpiperidin-3-yl)-5-(*S)-(6-isobutyl-4- methylpyridin-3-yl)-4-oxo-4,5-dihydro-3H-1-thia-3,5,8- triazaacenaphthylene-2-carboxamide;::US10800792, Example 669::US10822348, Example 722

SMILES CC(C)Cc1cc(C)c(cn1)-n1c2ccnc3sc(C(=O)N[C@@H]4CCCN(C4)C(=O)C=C)c([nH]c1=O)c23

InChI Key

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 468007   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM468007((R)-N-(1-Acryloylpiperidin-3-yl)-5-(*S)-(6-isobuty...)
Affinity DataKi:  145nMAssay Description:Inhibition of full length N-terminal GST-tagged human BTK expressed in Sf21 cells assessed as inhibition constant using NH2-KKKAPFSWYLPEEG as substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK [386-659](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM468007((R)-N-(1-Acryloylpiperidin-3-yl)-5-(*S)-(6-isobuty...)
Affinity DataIC50:  25.1nMAssay Description:A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM468007((R)-N-(1-Acryloylpiperidin-3-yl)-5-(*S)-(6-isobuty...)
Affinity DataIC50:  7.94nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK [386-659](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM468007((R)-N-(1-Acryloylpiperidin-3-yl)-5-(*S)-(6-isobuty...)
Affinity DataIC50:  7.94nMAssay Description:A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK [386-659](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM468007((R)-N-(1-Acryloylpiperidin-3-yl)-5-(*S)-(6-isobuty...)
Affinity DataIC50:  398nMAssay Description:A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent