BDBM470293 US10815206, Compound I-76::US11332451, Compound I-76::US11370764, Compound I-76::US11407736, Compound I-76

SMILES COC(=O)C(C)(C)C#Cc1ccc2OC[C@H](NC(=O)c3n[nH]c(Cc4ccccc4)n3)C(=O)N(C)c2c1

InChI Key

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 470293   

TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM470293(US10815206, Compound I-76 | US11332451, Compound I...)
Affinity DataIC50:  44.9nMAssay Description:A 500 ml stock volume of 5× Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM470293(US10815206, Compound I-76 | US11332451, Compound I...)
Affinity DataIC50:  44.9nMAssay Description:A 500 ml stock volume of 5× Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM470293(US10815206, Compound I-76 | US11332451, Compound I...)
Affinity DataIC50:  44.9nMAssay Description:ADP-Glo™ (Promega, Madison, Wis., USA) reagents were thawed at ambient temperature. Kinase Detection Reagent was prepared by mixing kinase detection ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM470293(US10815206, Compound I-76 | US11332451, Compound I...)
Affinity DataIC50:  44.9nMAssay Description:A 500 ml stock volume of 5× Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM470293(US10815206, Compound I-76 | US11332451, Compound I...)
Affinity DataIC50:  44.9nMAssay Description:ADP-Glo (Promega, Madison, Wis., USA) reagents were thawed at ambient temperature. Kinase Detection Reagent was prepared by mixing kinase detection b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent