BDBM473880 5-(4-(4-chloro-3,5- dimethylphenoxy)- N-isobutylphenyl- sulfonamido)-2- hydroxybenzoic acid::US10858316, Compound JY-5-304
SMILES CC(C)CN(c1ccc(O)c(c1)C(O)=O)S(=O)(=O)c1ccc(Oc2cc(C)c(Cl)c(C)c2)cc1
InChI Key InChIKey=QVDQXTZYQIUQHH-UHFFFAOYSA-N
Data 5 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 473880
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University of Maryland, Baltimore
US Patent
University of Maryland, Baltimore
US Patent
Affinity DataKi: 586nMAssay Description:Molecular modeling and SILCS functional group affinity mapping (FragMaps) of the Mcl-1 binding site indicated that the carboxylic acid of designed mo...More data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University of Maryland, Baltimore
US Patent
University of Maryland, Baltimore
US Patent
Affinity DataKi: 586nMAssay Description:Molecular modeling and SILCS functional group affinity mapping (FragMaps) of the Mcl-1 binding site indicated that the carboxylic acid of designed mo...More data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University of Maryland, Baltimore
US Patent
University of Maryland, Baltimore
US Patent
Affinity DataKi: 586nMAssay Description:Inhibition of FITC-labelled BAK BH3 peptide to 6His-MBP tagged recombinant human MCL-1 (172 to 327 residues) expressed in Escherichia coli assessed a...More data for this Ligand-Target Pair
TargetIsoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)(Homo sapiens (Human))
University of Maryland, Baltimore
US Patent
University of Maryland, Baltimore
US Patent
Affinity DataKi: 2.91E+3nMAssay Description:Molecular modeling and SILCS functional group affinity mapping (FragMaps) of the Mcl-1 binding site indicated that the carboxylic acid of designed mo...More data for this Ligand-Target Pair
Affinity DataKi: 2.91E+3nMAssay Description:Binding affinity to BCL-xL (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair