BDBM474284 7-(4-fluorophenyl)-2-((3-fluoropyridin-2-yl) methyl)-8-(1-methyl-1H-benzo[d]imidazol-6-yl)-[1,2, 4]triazolo[l,5-c]pyrimidin-5-amine::US10858365, Compound 69

SMILES Cn1cnc2ccc(cc12)-c1c(nc(N)n2nc(Cc3ncccc3F)nc12)-c1ccc(F)cc1

InChI Key InChIKey=MFOVNQPXJSGJPL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 474284   

TargetAdenosine receptor A2a(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM474284(7-(4-fluorophenyl)-2-((3-fluoropyridin-2-yl) methy...)
Affinity DataIC50:  0.100nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A1(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM474284(7-(4-fluorophenyl)-2-((3-fluoropyridin-2-yl) methy...)
Affinity DataIC50:  22nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Mus musculus)
TBA

US Patent
LigandPNGBDBM474284(7-(4-fluorophenyl)-2-((3-fluoropyridin-2-yl) methy...)
Affinity DataIC50:  0.300nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2b(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM474284(7-(4-fluorophenyl)-2-((3-fluoropyridin-2-yl) methy...)
Affinity DataIC50:  4.69nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent