BDBM474287 2-((3-(difluoromethoxy)pyridin-2-yl)methyl)-7- (4-fluorophenyl)-8-(imidazo[l,2-a]pyridin-6-yl)- [1,2,4 triazolo[l,5-c]pyrimidin-5-amine::US10858365, Compound 73

SMILES Nc1nc(-c2ccc(F)cc2)c(-c2ccc3nncn3c2)c2nc(Cc3ncccc3OC(F)F)nn12

InChI Key InChIKey=KYCYXWHIIAISQF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 474287   

TargetAdenosine receptor A2a(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM474287(2-((3-(difluoromethoxy)pyridin-2-yl)methyl)-7- (4-...)
Affinity DataIC50:  0.100nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A1(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM474287(2-((3-(difluoromethoxy)pyridin-2-yl)methyl)-7- (4-...)
Affinity DataIC50:  11nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Mus musculus)
TBA

US Patent
LigandPNGBDBM474287(2-((3-(difluoromethoxy)pyridin-2-yl)methyl)-7- (4-...)
Affinity DataIC50:  0.400nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2b(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM474287(2-((3-(difluoromethoxy)pyridin-2-yl)methyl)-7- (4-...)
Affinity DataIC50:  4.80nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent