BDBM474333 2-(2-(dimethylamino)ethyl)-7-(4-fl uorophenyl )-8- (3-methylimidazo[ l,2-a]pyridin-6-yl)-[l,2,4]tria zolo[1,5-c]pyrimidin-5-amine::US10858365, Compound 120

SMILES CN(C)CCc1nc2c(-c3ccc4ncc(C)n4c3)c(nc(N)n2n1)-c1ccc(F)cc1

InChI Key InChIKey=RJODVEWAMLKSIX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 474333   

TargetAdenosine receptor A2a(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM474333(2-(2-(dimethylamino)ethyl)-7-(4-fl uorophenyl )-8-...)
Affinity DataIC50:  0.600nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A1(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM474333(2-(2-(dimethylamino)ethyl)-7-(4-fl uorophenyl )-8-...)
Affinity DataIC50:  66.7nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Mus musculus)
TBA

US Patent
LigandPNGBDBM474333(2-(2-(dimethylamino)ethyl)-7-(4-fl uorophenyl )-8-...)
Affinity DataIC50:  9.5nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2b(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM474333(2-(2-(dimethylamino)ethyl)-7-(4-fl uorophenyl )-8-...)
Affinity DataIC50:  146nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent