BDBM475993 US10865208, Compound I-51::{(2R,3S,4R,5R)-5-[4-amino-3-(ethylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]- 3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate

SMILES CCSc1nn([C@@H]2O[C@H](COS(N)(=O)=O)[C@@H](O)[C@H]2O)c2ncnc(N)c12

InChI Key InChIKey=MINMBWMRXQZRGS-JTFADIMSSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 475993   

TargetUbiquitin-like modifier-activating enzyme ATG7(Homo sapiens (Human))
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM475993(US10865208, Compound I-51 | {(2R,3S,4R,5R)-5-[4-am...)
Affinity DataIC50:  35nMAssay Description:The total volume of the ATG7 enzymatic assay is 50 μL and contains 50 mM HEPES Hemisodium (pH 7.5), 0.05% BSA, 0.01% Tween-20, 25 mM NaCl, 5 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin-like modifier-activating enzyme ATG7(Homo sapiens (Human))
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM475993(US10865208, Compound I-51 | {(2R,3S,4R,5R)-5-[4-am...)
Affinity DataIC50:  160nMAssay Description:Inhibition of ATG7 in human 293HEK cells assessed as inhibition of ATG7:ATG8 thioester formation after 8 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUbiquitin-like modifier-activating enzyme ATG7(Homo sapiens (Human))
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM475993(US10865208, Compound I-51 | {(2R,3S,4R,5R)-5-[4-am...)
Affinity DataIC50:  22nMAssay Description:Inhibition of recombinant His-tagged human ATG7 incubated for 105 mins in presence of GST-tagged ATG3 and Flag-tagged Gabarap and measured after 2 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed