BDBM478942 2-(4-(1-acryloyl-1,2,3,6-tetrahydropyridin-4-yl)-3-fluorophenyl)-N-(5- cyclopropyl-1H-pyrazol-3-yl)propanamide::US10894786, Comp. No 44::US10894786, Comp. No 45

SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(C2=CCN(CC2)C(=O)C=C)c(F)c1

InChI Key

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 478942   

TargetCyclin-dependent kinase 12(Homo sapiens)
Aurigene Discovery Technologies

US Patent
LigandPNGBDBM478942(2-(4-(1-acryloyl-1,2,3,6-tetrahydropyridin-4-yl)-3...)
Affinity DataIC50:  9nMAssay Description:The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 13(Homo sapiens (Human))
Aurigene Discovery Technologies

US Patent
LigandPNGBDBM478942(2-(4-(1-acryloyl-1,2,3,6-tetrahydropyridin-4-yl)-3...)
Affinity DataIC50:  5.80nMAssay Description:LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 7(Homo sapiens (Human))
Aurigene Discovery Technologies

US Patent
LigandPNGBDBM478942(2-(4-(1-acryloyl-1,2,3,6-tetrahydropyridin-4-yl)-3...)
Affinity DataIC50:  5.76E+3nMAssay Description:The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 12(Homo sapiens)
Aurigene Discovery Technologies

US Patent
LigandPNGBDBM478942(2-(4-(1-acryloyl-1,2,3,6-tetrahydropyridin-4-yl)-3...)
Affinity DataIC50:  445nMAssay Description:The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 13(Homo sapiens (Human))
Aurigene Discovery Technologies

US Patent
LigandPNGBDBM478942(2-(4-(1-acryloyl-1,2,3,6-tetrahydropyridin-4-yl)-3...)
Affinity DataIC50:  260nMAssay Description:LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 7(Homo sapiens (Human))
Aurigene Discovery Technologies

US Patent
LigandPNGBDBM478942(2-(4-(1-acryloyl-1,2,3,6-tetrahydropyridin-4-yl)-3...)
Affinity DataIC50:  880nMAssay Description:The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent