BDBM479169 US10894789, Compound 125

SMILES COc1ccc(cc1)-c1cn(C)nc1C(=O)N1CC(F)(F)C[C@@H](C)C1CNc1cnc(cn1)C(F)(F)F

InChI Key InChIKey=BZYRMGPJRHIWFZ-IKJXHCRLSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 479169   

TargetOrexin receptor type 2(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM479169(US10894789, Compound 125)
Affinity DataIC50: >5.00E+3nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM479169(US10894789, Compound 125)
Affinity DataIC50:  2nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM479169(US10894789, Compound 125)
Affinity DataIC50: >5.00E+3nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM479169(US10894789, Compound 125)
Affinity DataIC50:  4nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent