BDBM479499 ML300-based SC inhibitor 38

SMILES COc1cc(ccc1N(Cc1cccc(Cl)c1)C(=O)Cn1nnc2ccccc12)-c1cn[nH]c1

InChI Key InChIKey=ZJWZLVITQIYDKL-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 479499   

TargetReplicase polyprotein 1ab(SARS-CoV)
Cleveland Clinic

LigandPNGBDBM479499(ML300-based SC inhibitor 38)
Affinity DataIC50:  208nMAssay Description:The protease activity and subsequent 10-point IC50 curves were spectroscopically determined using a scaled down, end point assay adapted from a previ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cleveland Clinic

LigandPNGBDBM479499(ML300-based SC inhibitor 38)
Affinity DataEC50:  2.01E+3nMAssay Description:Confluent monolayers of Vero E6 ACE2 cells in 12-well plates were washed once with DMEM and infected with approximately 50 plaque forming units (PFUs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cleveland Clinic

LigandPNGBDBM479499(ML300-based SC inhibitor 38)
Affinity DataEC50:  2.30E+3nMAssay Description:Briefly, Vero E6 ACE2 cells were cultured in 96-well flat-bottom plates at a density of 2 × 104 cells per well. Following infection of the cells with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cleveland Clinic

LigandPNGBDBM479499(ML300-based SC inhibitor 38)
Affinity DataIC50:  197nMAssay Description:The protease activity and subsequent 10-point IC50 curves were spectroscopically determined using a scaled down, end point assay adapted from a previ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed